Du Zhong Bark Extract

Classification and content of main active ingredients

1. Iridoids

Representative ingredients:

Geniposide: 50-70% of total iridoids.

Aucubin: has anti-inflammatory and antioxidant effects.

Content range: about 0.5-2% in dry bark (due to large differences in extraction process).

Function:

Promote osteoblast differentiation (prevent osteoporosis);

Regulate blood sugar (by activating the insulin signaling pathway);

Protect liver (reduce chemical liver damage).

2. Flavonoids

Representative ingredients:

Quercetin: 10-30% of total flavonoids;

Kaempferol;

Rutin.

Content range: about 0.1-1% of total flavonoids in dry bark, and the content of aglycone form (such as quercetin) is lower.

Functions:

Antioxidant (scavenging free radicals, IC₅₀ value is about 10-50 μM);

Anti-inflammatory (inhibiting COX-2 and NF-κB pathways);

Cardiovascular protection (lowering LDL cholesterol).

3. Polysaccharides

Content range: about 2-10% (dry weight) in bark, up to 50-80% after purification.

Structural characteristics: mainly β-glucan, with a molecular weight of about 10-100 kDa.

Function:

Immunomodulation (activating macrophages, promoting IL-6 secretion);

Anti-tumor auxiliary effect (enhancing chemotherapy sensitivity);

Intestinal health (promoting lactic acid bacteria proliferation as a prebiotic).

4. Gutta-percha

Content range: about 10-30% in dry bark.

Characteristics: natural rubber-like polymer compound with viscosity and elasticity.

Function:

Antibacterial (inhibiting Staphylococcus aureus and Escherichia coli);

Moisturizing (locking water in cosmetics).

5. Lignans

Representative ingredient: Pinoresinol diglucoside.

Content range: about 0.1-0.5% in dry bark.

Function:

Estrogen-like activity (regulating menopausal symptoms);

Antioxidant (scavenging DPPH free radicals).

6. Phenolic Acids

Representative ingredients: chlorogenic acid, caffeic acid.

Content range: about 0.01-0.2% in dry bark.

Functions:

Antioxidant (synergistic with flavonoids);

Antibacterial (inhibits biofilm formation).

7. Other ingredients

Amino acids: Contains more than 17 kinds, including γ-aminobutyric acid (GABA, regulates blood pressure);

Trace elements: zinc, iron, calcium, magnesium, etc.;

Vitamins: Vitamin C, vitamin E (trace amounts).

Pharmacological effects of key ingredients

1. Geniposide:

Mechanism: Promotes glucose uptake by activating the AMPK pathway;

Research support: It can reduce fasting blood sugar by 20-30% (dose-dependent) in mouse experiments.

2. Quercetin:

Mechanism: Inhibits the formation of AGEs (advanced glycation end products) and delays diabetic complications;

Dosage: 50-100 mg/kg daily can significantly improve insulin resistance.

3. Polysaccharides:

Mechanism: Activates innate immunity through the TLR4/NF-κB pathway;

Application: Combined with chemotherapy drugs, it can enhance the apoptosis rate of tumor cells (in vitro experiments +40%).

Analysis Of Eucommia Leaf Extract

1.Featured Eucommia leaf

2.Physical process

3.Mechanical movement breaks down plant tissue

4.Physical Desliming

5.Precision filtration

6.Oncentrating The Remain Solution

7.Precipitation, Purification And Extraction

8.Concentration Sterilisation Freeze-Drying Powdering

9.End product